Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 25/09/21 13:30 | 25/09/21 13:29 | Manchester United | Aston Villa | 0:1 | 2 - 4 puntos |
| 25/09/21 13:30 | 25/09/21 13:29 | FC Chelsea | Manchester City | 0:1 | 2 - 4 puntos |
| 25/09/21 16:00 | 25/09/21 15:59 | Leeds United | West Ham United | 1:2 | 2 - 4 puntos |
| 25/09/21 16:00 | 25/09/21 15:59 | Leicester City | FC Burnley | 2:2 | 2 - 4 puntos |
| 25/09/21 16:00 | 25/09/21 15:59 | FC Watford | Newcastle United | 1:1 | 2 - 4 puntos |
| 25/09/21 16:00 | 25/09/21 15:59 | FC Everton | Norwich City | 2:0 | 2 - 4 puntos |
| 25/09/21 18:30 | 25/09/21 18:29 | Brentford FC | Liverpool FC | 3:3 | 2 - 4 puntos |
| 26/09/21 15:00 | 26/09/21 14:59 | FC Southampton | Wolverhampton Wanderers | 0:1 | 2 - 4 puntos |
| 26/09/21 17:30 | 26/09/21 17:29 | Arsenal FC | Tottenham | 3:1 | 2 - 4 puntos |
| 27/09/21 21:00 | 27/09/21 20:59 | Crystal Palace | Brighton and Hove Albion | 1:1 | 2 - 4 puntos |