Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 3/12/21 20:30 | 3/12/21 20:30 | 1. FC Union Berlin | RB Leipzig | 2:1 | 4 - 5 - 3 |
| 4/12/21 15:30 | 4/12/21 15:30 | FSV Mainz 05 | VfL Wolfsburg | 3:0 | 3 - 4 - 3 |
| 4/12/21 15:30 | 4/12/21 15:30 | 1899 Hoffenheim | Eintracht Frankfurt | 3:2 | 3 - 4 - 5 |
| 4/12/21 15:30 | 4/12/21 15:30 | Bayer Leverkusen | SpVgg Greuther Fürth | 7:1 | 2 - 8 - 8 |
| 4/12/21 15:30 | 4/12/21 15:30 | Arminia Bielefeld | 1. FC Köln | 1:1 | 6 - 4 - 3 |
| 4/12/21 15:30 | 4/12/21 15:30 | FC Augsburg | VfL Bochum | 2:3 | 3 - 4 - 5 |
| 4/12/21 18:30 | 4/12/21 18:30 | Borussia Dortmund | FC Bayern de Múnich | 2:3 | 5 - 5 - 3 |
| 5/12/21 15:30 | 5/12/21 15:30 | VfB Stuttgart | Hertha BSC | 2:2 | 3 - 5 - 5 |
| 5/12/21 17:30 | 5/12/21 17:30 | Bor. Mönchengladbach | SC Freiburg | 0:6 | 2 - 5 - 7 |