Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 17/09/21 20:30 | 17/09/21 20:30 | Hertha BSC | SpVgg Greuther Fürth | 2:1 | 2 - 8 - 8 |
| 18/09/21 15:30 | 18/09/21 15:30 | FC Bayern de Múnich | VfL Bochum | 7:0 | 2 - 8 - 8 |
| 18/09/21 15:30 | 18/09/21 15:30 | Arminia Bielefeld | 1899 Hoffenheim | 0:0 | 6 - 4 - 3 |
| 18/09/21 15:30 | 18/09/21 15:30 | FC Augsburg | Bor. Mönchengladbach | 1:0 | 8 - 5 - 2 |
| 18/09/21 15:30 | 18/09/21 15:30 | FSV Mainz 05 | SC Freiburg | 0:0 | 3 - 3 - 5 |
| 18/09/21 18:30 | 18/09/21 18:30 | 1. FC Köln | RB Leipzig | 1:1 | 7 - 6 - 2 |
| 19/09/21 15:30 | 19/09/21 15:30 | VfB Stuttgart | Bayer Leverkusen | 1:3 | 6 - 6 - 2 |
| 19/09/21 17:30 | 19/09/21 17:30 | Borussia Dortmund | 1. FC Union Berlin | 4:2 | 2 - 8 - 8 |
| 19/09/21 19:30 | 19/09/21 19:30 | VfL Wolfsburg | Eintracht Frankfurt | 1:1 | 2 - 5 - 7 |