Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 26/11/21 20:30 | 26/11/21 20:30 | VfB Stuttgart | FSV Mainz 05 | 2:1 | 6 - 4 - 5 |
| 27/11/21 15:30 | 27/11/21 15:30 | 1. FC Köln | Bor. Mönchengladbach | 4:1 | 5 - 6 - 4 |
| 27/11/21 15:30 | 27/11/21 15:30 | Hertha BSC | FC Augsburg | 1:1 | 4 - 6 - 5 |
| 27/11/21 15:30 | 27/11/21 15:30 | VfL Wolfsburg | Borussia Dortmund | 1:3 | 6 - 6 - 4 |
| 27/11/21 15:30 | 27/11/21 15:30 | SpVgg Greuther Fürth | 1899 Hoffenheim | 3:6 | 9 - 7 - 3 |
| 27/11/21 15:30 | 27/11/21 15:30 | VfL Bochum | SC Freiburg | 2:1 | 6 - 5 - 4 |
| 27/11/21 18:30 | 27/11/21 18:30 | FC Bayern de Múnich | Arminia Bielefeld | 1:0 | 3 - 9 - 9 |
| 28/11/21 15:30 | 28/11/21 15:30 | Eintracht Frankfurt | 1. FC Union Berlin | 2:1 | 4 - 4 - 7 |
| 28/11/21 17:30 | 28/11/21 17:30 | RB Leipzig | Bayer Leverkusen | 1:3 | 4 - 7 - 6 |