Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 15/10/21 20:30 | 15/10/21 20:30 | 1899 Hoffenheim | 1. FC Köln | 5:0 | 5 - 4 - 5 |
| 16/10/21 15:30 | 16/10/21 15:30 | 1. FC Union Berlin | VfL Wolfsburg | 2:0 | 5 - 6 - 4 |
| 16/10/21 15:30 | 16/10/21 15:30 | Eintracht Frankfurt | Hertha BSC | 1:2 | 3 - 8 - 9 |
| 16/10/21 15:30 | 16/10/21 15:30 | Borussia Dortmund | FSV Mainz 05 | 3:1 | 3 - 9 - 9 |
| 16/10/21 15:30 | 16/10/21 15:30 | SpVgg Greuther Fürth | VfL Bochum | 0:1 | 5 - 4 - 5 |
| 16/10/21 15:30 | 16/10/21 15:30 | SC Freiburg | RB Leipzig | 1:1 | 5 - 5 - 4 |
| 16/10/21 18:30 | 16/10/21 18:30 | Bor. Mönchengladbach | VfB Stuttgart | 1:1 | 3 - 5 - 9 |
| 17/10/21 15:30 | 17/10/21 15:30 | Bayer Leverkusen | FC Bayern de Múnich | 1:5 | 6 - 7 - 4 |
| 17/10/21 17:30 | 17/10/21 17:30 | FC Augsburg | Arminia Bielefeld | 1:1 | 4 - 5 - 8 |