| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 25/09/24 18:45 | AZ Alkmaar | IF Elfsborg Boras | 3:2 |
| 25/09/24 18:45 | FK Bodö/Glimt | FC Porto | 3:2 |
| 25/09/24 21:00 | RSC Anderlecht | Ferencvaros Budapest | 2:1 |
| 25/09/24 21:00 | OGC Niza | Real Sociedad de Fútbol | 1:1 |
| 25/09/24 21:00 | PFC Ludogorets Razgrad | Slavia Praga | 0:2 |
| 25/09/24 21:00 | Galatasaray Estanbul | PAOK Salónica | 3:1 |
| 25/09/24 21:00 | FC Midtjylland | 1899 Hoffenheim | 1:1 |
| 25/09/24 21:00 | Dinamo de Kiev | Lazio Roma | 0:3 |
| 25/09/24 21:00 | Manchester United | FC Twente Enschede | 1:1 |
| 26/09/24 18:45 | Malmö FF | Glasgow Rangers | 0:2 |
| 26/09/24 18:45 | Fenerbahçe SK | Royale Union Saint-Gilloise | 2:1 |
| 26/09/24 21:00 | FCSB Bukarest | Rigas Futbola Skola | 4:1 |
| 26/09/24 21:00 | Olympique Lyon | Olympiacos Piräus | 2:0 |
| 26/09/24 21:00 | AS Roma | Athletic Club | 1:1 |
| 26/09/24 21:00 | Eintracht Frankfurt | Viktoria Pilsen | 3:3 |
| 26/09/24 21:00 | Ajax Amsterdam | Besiktas JK | 4:0 |
| 26/09/24 21:00 | Sporting Braga | Maccabi Tel Aviv | 2:1 |
| 26/09/24 21:35 | Tottenham | Qarabag | 3:0 |