| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 21/01/25 16:30 | Galatasaray Estanbul | Dinamo de Kiev | 3:3 |
| 22/01/25 16:30 | Besiktas JK | Athletic Club | 4:1 |
| 23/01/25 18:45 | AZ Alkmaar | AS Roma | 1:0 |
| 23/01/25 18:45 | Malmö FF | FC Twente Enschede | 2:3 |
| 23/01/25 18:45 | FK Bodö/Glimt | Maccabi Tel Aviv | 3:1 |
| 23/01/25 18:45 | Qarabag | FCSB Bukarest | 2:3 |
| 23/01/25 18:45 | Viktoria Pilsen | RSC Anderlecht | 2:0 |
| 23/01/25 18:45 | 1899 Hoffenheim | Tottenham | 2:3 |
| 23/01/25 18:45 | FC Porto | Olympiacos Piräus | 0:1 |
| 23/01/25 18:45 | Fenerbahçe SK | Olympique Lyon | 0:0 |
| 23/01/25 21:00 | Rigas Futbola Skola | Ajax Amsterdam | 1:0 |
| 23/01/25 21:00 | PFC Ludogorets Razgrad | FC Midtjylland | 0:2 |
| 23/01/25 21:00 | Royale Union Saint-Gilloise | Sporting Braga | 2:1 |
| 23/01/25 21:00 | IF Elfsborg Boras | OGC Niza | 1:0 |
| 23/01/25 21:00 | Eintracht Frankfurt | Ferencvaros Budapest | 2:0 |
| 23/01/25 21:00 | Manchester United | Glasgow Rangers | 2:1 |
| 23/01/25 21:00 | Lazio Roma | Real Sociedad de Fútbol | 3:1 |
| 23/01/25 21:00 | PAOK Salónica | Slavia Praga | 2:0 |