| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 30/01/25 21:00 | FCSB Bukarest | Manchester United | 0:2 |
| 30/01/25 21:00 | RSC Anderlecht | 1899 Hoffenheim | 3:4 |
| 30/01/25 21:00 | Athletic Club | Viktoria Pilsen | 3:1 |
| 30/01/25 21:00 | OGC Niza | FK Bodö/Glimt | 1:1 |
| 30/01/25 21:00 | Olympique Lyon | PFC Ludogorets Razgrad | 1:1 |
| 30/01/25 21:00 | FC Midtjylland | Fenerbahçe SK | 2:2 |
| 30/01/25 21:00 | Dinamo de Kiev | Rigas Futbola Skola | 1:0 |
| 30/01/25 21:00 | FC Twente Enschede | Besiktas JK | 1:0 |
| 30/01/25 21:00 | AS Roma | Eintracht Frankfurt | 2:0 |
| 30/01/25 21:00 | Glasgow Rangers | Royale Union Saint-Gilloise | 2:1 |
| 30/01/25 21:00 | Slavia Praga | Malmö FF | 2:2 |
| 30/01/25 21:00 | Tottenham | IF Elfsborg Boras | 3:0 |
| 30/01/25 21:00 | Maccabi Tel Aviv | FC Porto | 0:1 |
| 30/01/25 21:00 | Ajax Amsterdam | Galatasaray Estanbul | 2:1 |
| 30/01/25 21:00 | Ferencvaros Budapest | AZ Alkmaar | 4:3 |
| 30/01/25 21:00 | Sporting Braga | Lazio Roma | 1:0 |
| 30/01/25 21:00 | Olympiacos Piräus | Qarabag | 3:0 |
| 30/01/25 21:00 | Real Sociedad de Fútbol | PAOK Salónica | 2:0 |