| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 13/02/25 18:45 | Royale Union Saint-Gilloise | Ajax Amsterdam | 0:2 |
| 13/02/25 18:45 | Fenerbahçe SK | RSC Anderlecht | 3:0 |
| 13/02/25 18:45 | FC Midtjylland | Real Sociedad de Fútbol | 1:2 |
| 13/02/25 18:45 | Ferencvaros Budapest | Viktoria Pilsen | 1:0 |
| 13/02/25 21:00 | FC Porto | AS Roma | 1:1 |
| 13/02/25 21:00 | PAOK Salónica | FCSB Bukarest | 1:2 |
| 13/02/25 21:00 | AZ Alkmaar | Galatasaray Estanbul | 4:1 |
| 13/02/25 21:00 | FC Twente Enschede | FK Bodö/Glimt | 2:1 |