Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 10/09/21 2:20 | 10/09/21 2:20 | Tampa Bay Buccaneers | Dallas Cowboys | 31:29 | 3 - 10 - 10 |
| 12/09/21 19:00 | 12/09/21 19:00 | Houston Texans | Jacksonville Jaguars | 37:21 | 5 - 10 - 4 |
| 12/09/21 19:00 | 12/09/21 19:00 | Detroit Lions | San Francisco 49ers | 33:41 | 10 - 10 - 3 |
| 12/09/21 19:00 | 12/09/21 19:00 | Cincinnati Bengals | Minnesota Vikings | 27:24OT | 6 - 10 - 3 |
| 12/09/21 19:00 | 12/09/21 19:00 | Carolina Panthers | New York Jets | 19:14 | 3 - 10 - 7 |
| 12/09/21 19:00 | 12/09/21 19:00 | Buffalo Bills | Pittsburgh Steelers | 16:23 | 3 - 10 - 8 |
| 12/09/21 19:00 | 12/09/21 19:00 | Atlanta Falcons | Philadelphia Eagles | 6:32 | 4 - 10 - 5 |
| 12/09/21 19:00 | 12/09/21 19:00 | Washington Football Team | Los Angeles Chargers | 16:20 | 5 - 10 - 4 |
| 12/09/21 19:00 | 12/09/21 19:00 | Tennessee Titans | Arizona Cardinals | 13:38 | 3 - 10 - 6 |
| 12/09/21 19:00 | 12/09/21 19:00 | Indianapolis Colts | Seattle Seahawks | 16:28 | 6 - 10 - 3 |
| 12/09/21 22:25 | 12/09/21 22:25 | New York Giants | Denver Broncos | 13:27 | 4 - 10 - 4 |
| 12/09/21 22:25 | 12/09/21 22:25 | New Orleans Saints | Green Bay Packers | 38:3 | 7 - 10 - 3 |
| 12/09/21 22:25 | 12/09/21 22:25 | New England Patriots | Miami Dolphins | 16:17 | 4 - 10 - 4 |
| 12/09/21 22:25 | 12/09/21 22:25 | Kansas City Chiefs | Cleveland Browns | 33:29 | 3 - 10 - 10 |
| 13/09/21 2:20 | 13/09/21 2:20 | Los Angeles Rams | Chicago Bears | 34:14 | 3 - 10 - 10 |
| 14/09/21 2:15 | 14/09/21 2:15 | Las Vegas Raiders | Baltimore Ravens | 33:27OT | 7 - 10 - 3 |