Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 10/12/21 2:20 | 10/12/21 2:20 | Minnesota Vikings | Pittsburgh Steelers | 36:28 | 4 - 10 - 5 |
| 12/12/21 19:00 | 12/12/21 19:00 | Cleveland Browns | Baltimore Ravens | 24:22 | 5 - 10 - 4 |
| 12/12/21 19:00 | 12/12/21 19:00 | Carolina Panthers | Atlanta Falcons | 21:29 | 4 - 10 - 5 |
| 12/12/21 19:00 | 12/12/21 19:00 | New York Jets | New Orleans Saints | 9:30 | 7 - 10 - 3 |
| 12/12/21 19:00 | 12/12/21 19:00 | Kansas City Chiefs | Las Vegas Raiders | 48:9 | 3 - 10 - 10 |
| 12/12/21 19:00 | 12/12/21 19:00 | Houston Texans | Seattle Seahawks | 13:33 | 10 - 10 - 3 |
| 12/12/21 19:00 | 12/12/21 19:00 | Tennessee Titans | Jacksonville Jaguars | 20:0 | 3 - 10 - 10 |
| 12/12/21 19:00 | 12/12/21 19:00 | Washington Football Team | Dallas Cowboys | 20:27 | 6 - 10 - 3 |
| 12/12/21 22:05 | 12/12/21 22:05 | Denver Broncos | Detroit Lions | 38:10 | 3 - 10 - 10 |
| 12/12/21 22:05 | 12/12/21 22:05 | Los Angeles Chargers | New York Giants | 37:21 | 3 - 10 - 10 |
| 12/12/21 22:25 | 12/12/21 22:25 | Tampa Bay Buccaneers | Buffalo Bills | 33:27OT | 3 - 10 - 7 |
| 12/12/21 22:25 | 12/12/21 22:25 | Cincinnati Bengals | San Francisco 49ers | 23:26OT | 4 - 10 - 4 |
| 13/12/21 2:20 | 13/12/21 2:20 | Green Bay Packers | Chicago Bears | 45:30 | 3 - 10 - 10 |
| 14/12/21 2:15 | 14/12/21 2:15 | Arizona Cardinals | Los Angeles Rams | 23:30 | 3 - 10 - 6 |