Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 17/12/21 2:20 | 17/12/21 2:20 | Los Angeles Chargers | Kansas City Chiefs | 28:34OT | 6 - 10 - 3 |
| 19/12/21 2:15 | 19/12/21 2:15 | Indianapolis Colts | New England Patriots | 27:17 | 5 - 10 - 4 |
| 19/12/21 19:00 | 19/12/21 19:00 | Buffalo Bills | Carolina Panthers | 31:14 | 3 - 10 - 10 |
| 19/12/21 19:00 | 19/12/21 19:00 | Miami Dolphins | New York Jets | 31:24 | 3 - 10 - 10 |
| 19/12/21 19:00 | 19/12/21 19:00 | Detroit Lions | Arizona Cardinals | 30:12 | 10 - 10 - 3 |
| 19/12/21 19:00 | 19/12/21 19:00 | Pittsburgh Steelers | Tennessee Titans | 19:13 | 4 - 10 - 4 |
| 19/12/21 19:00 | 19/12/21 19:00 | Jacksonville Jaguars | Houston Texans | 16:30 | 4 - 10 - 4 |
| 19/12/21 19:00 | 19/12/21 19:00 | New York Giants | Dallas Cowboys | 6:21 | 10 - 10 - 3 |
| 19/12/21 22:05 | 19/12/21 22:05 | San Francisco 49ers | Atlanta Falcons | 31:13 | 3 - 10 - 10 |
| 19/12/21 22:05 | 19/12/21 22:05 | Denver Broncos | Cincinnati Bengals | 10:15 | 4 - 10 - 4 |
| 19/12/21 22:25 | 19/12/21 22:25 | Baltimore Ravens | Green Bay Packers | 30:31 | 8 - 10 - 3 |
| 20/12/21 2:20 | 20/12/21 2:20 | Tampa Bay Buccaneers | New Orleans Saints | 0:9 | 3 - 10 - 10 |
| 20/12/21 23:00 | 20/12/21 23:00 | Cleveland Browns | Las Vegas Raiders | 14:16 | 3 - 10 - 6 |
| 21/12/21 2:15 | 21/12/21 2:15 | Chicago Bears | Minnesota Vikings | 9:17 | 6 - 10 - 3 |
| 22/12/21 1:00 | 22/12/21 1:00 | Philadelphia Eagles | Washington Football Team | 27:17 | 4 - 10 - 5 |
| 22/12/21 1:00 | 22/12/21 1:00 | Los Angeles Rams | Seattle Seahawks | 20:10 | 3 - 10 - 10 |