Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 24/12/21 2:20 | 24/12/21 2:20 | Tennessee Titans | San Francisco 49ers | 20:17 | 4 - 10 - 4 |
| 25/12/21 22:30 | 25/12/21 22:30 | Green Bay Packers | Cleveland Browns | 24:22 | 3 - 10 - 10 |
| 26/12/21 2:15 | 26/12/21 2:15 | Arizona Cardinals | Indianapolis Colts | 16:22 | 4 - 10 - 4 |
| 26/12/21 19:00 | 26/12/21 19:00 | Cincinnati Bengals | Baltimore Ravens | 41:21 | 4 - 10 - 5 |
| 26/12/21 19:00 | 26/12/21 19:00 | Houston Texans | Los Angeles Chargers | 41:29 | 10 - 10 - 3 |
| 26/12/21 19:00 | 26/12/21 19:00 | Atlanta Falcons | Detroit Lions | 20:16 | 3 - 10 - 6 |
| 26/12/21 19:00 | 26/12/21 19:00 | New York Jets | Jacksonville Jaguars | 26:21 | 3 - 10 - 5 |
| 26/12/21 19:00 | 26/12/21 19:00 | Carolina Panthers | Tampa Bay Buccaneers | 6:32 | 10 - 10 - 3 |
| 26/12/21 19:00 | 26/12/21 19:00 | New England Patriots | Buffalo Bills | 21:33 | 4 - 10 - 5 |
| 26/12/21 19:00 | 26/12/21 19:00 | Minnesota Vikings | Los Angeles Rams | 23:30 | 7 - 10 - 3 |
| 26/12/21 19:00 | 26/12/21 19:00 | Philadelphia Eagles | New York Giants | 34:10 | 3 - 10 - 10 |
| 26/12/21 22:05 | 26/12/21 22:05 | Seattle Seahawks | Chicago Bears | 24:25 | 3 - 10 - 6 |
| 26/12/21 22:25 | 26/12/21 22:25 | Las Vegas Raiders | Denver Broncos | 17:13 | 3 - 10 - 5 |
| 26/12/21 22:25 | 26/12/21 22:25 | Kansas City Chiefs | Pittsburgh Steelers | 36:10 | 3 - 10 - 10 |
| 27/12/21 2:20 | 27/12/21 2:20 | Dallas Cowboys | Washington Football Team | 56:14 | 3 - 10 - 10 |
| 28/12/21 2:15 | 28/12/21 2:15 | New Orleans Saints | Miami Dolphins | 3:20 | 4 - 10 - 5 |