Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 17/09/21 2:20 | 17/09/21 2:20 | Washington Football Team | New York Giants | 30:29 | 3 - 10 - 5 |
| 19/09/21 19:00 | 19/09/21 19:00 | Chicago Bears | Cincinnati Bengals | 20:17 | 4 - 10 - 4 |
| 19/09/21 19:00 | 19/09/21 19:00 | Pittsburgh Steelers | Las Vegas Raiders | 17:26 | 3 - 10 - 6 |
| 19/09/21 19:00 | 19/09/21 19:00 | Indianapolis Colts | Los Angeles Rams | 24:27 | 10 - 10 - 3 |
| 19/09/21 19:00 | 19/09/21 19:00 | Philadelphia Eagles | San Francisco 49ers | 11:17 | 6 - 10 - 3 |
| 19/09/21 19:00 | 19/09/21 19:00 | Miami Dolphins | Buffalo Bills | 0:35 | 8 - 10 - 3 |
| 19/09/21 19:00 | 19/09/21 19:00 | Jacksonville Jaguars | Denver Broncos | 13:23 | 5 - 10 - 3 |
| 19/09/21 19:00 | 19/09/21 19:00 | New York Jets | New England Patriots | 6:25 | 8 - 10 - 3 |
| 19/09/21 19:00 | 19/09/21 19:00 | Carolina Panthers | New Orleans Saints | 26:7 | 9 - 10 - 3 |
| 19/09/21 19:00 | 19/09/21 19:00 | Cleveland Browns | Houston Texans | 31:21 | 3 - 10 - 7 |
| 19/09/21 22:05 | 19/09/21 22:05 | Tampa Bay Buccaneers | Atlanta Falcons | 48:25 | 3 - 10 - 10 |
| 19/09/21 22:05 | 19/09/21 22:05 | Arizona Cardinals | Minnesota Vikings | 34:33 | 3 - 10 - 6 |
| 19/09/21 22:25 | 19/09/21 22:25 | Los Angeles Chargers | Dallas Cowboys | 17:20 | 5 - 10 - 3 |
| 19/09/21 22:25 | 19/09/21 22:25 | Seattle Seahawks | Tennessee Titans | 30:33OT | 3 - 10 - 8 |
| 20/09/21 2:20 | 20/09/21 2:20 | Baltimore Ravens | Kansas City Chiefs | 36:35 | 8 - 10 - 3 |
| 21/09/21 2:15 | 21/09/21 2:15 | Green Bay Packers | Detroit Lions | 35:17 | 3 - 10 - 8 |