Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 1/10/21 2:20 | 1/10/21 2:20 | Cincinnati Bengals | Jacksonville Jaguars | 24:21 | 3 - 10 - 10 |
| 3/10/21 19:00 | 3/10/21 19:00 | Atlanta Falcons | Washington Football Team | 30:34 | 4 - 10 - 4 |
| 3/10/21 19:00 | 3/10/21 19:00 | Miami Dolphins | Indianapolis Colts | 17:27 | 4 - 10 - 4 |
| 3/10/21 19:00 | 3/10/21 19:00 | Buffalo Bills | Houston Texans | 40:0 | 3 - 10 - 10 |
| 3/10/21 19:00 | 3/10/21 19:00 | Chicago Bears | Detroit Lions | 24:14 | 4 - 10 - 5 |
| 3/10/21 19:00 | 3/10/21 19:00 | Minnesota Vikings | Cleveland Browns | 7:14 | 5 - 10 - 4 |
| 3/10/21 19:00 | 3/10/21 19:00 | New Orleans Saints | New York Giants | 21:27OT | 3 - 10 - 10 |
| 3/10/21 19:00 | 3/10/21 19:00 | Dallas Cowboys | Carolina Panthers | 36:28 | 3 - 10 - 5 |
| 3/10/21 19:00 | 3/10/21 19:00 | Philadelphia Eagles | Kansas City Chiefs | 30:42 | 10 - 10 - 3 |
| 3/10/21 19:00 | 3/10/21 19:00 | New York Jets | Tennessee Titans | 27:24OT | 10 - 10 - 3 |
| 3/10/21 22:05 | 3/10/21 22:05 | Los Angeles Rams | Arizona Cardinals | 20:37 | 3 - 10 - 9 |
| 3/10/21 22:05 | 3/10/21 22:05 | San Francisco 49ers | Seattle Seahawks | 21:28 | 4 - 10 - 4 |
| 3/10/21 22:25 | 3/10/21 22:25 | Denver Broncos | Baltimore Ravens | 7:23 | 6 - 10 - 3 |
| 3/10/21 22:25 | 3/10/21 22:25 | Green Bay Packers | Pittsburgh Steelers | 27:17 | 3 - 10 - 9 |
| 4/10/21 2:20 | 4/10/21 2:20 | New England Patriots | Tampa Bay Buccaneers | 17:19 | 10 - 10 - 3 |
| 5/10/21 2:15 | 5/10/21 2:15 | Los Angeles Chargers | Las Vegas Raiders | 28:14 | 4 - 10 - 4 |