Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 22/10/21 2:20 | 22/10/21 2:20 | Cleveland Browns | Denver Broncos | 17:14 | 3 - 10 - 6 |
| 24/10/21 19:00 | 24/10/21 19:00 | Baltimore Ravens | Cincinnati Bengals | 17:41 | 3 - 10 - 10 |
| 24/10/21 19:00 | 24/10/21 19:00 | Miami Dolphins | Atlanta Falcons | 28:30 | 5 - 10 - 4 |
| 24/10/21 19:00 | 24/10/21 19:00 | Green Bay Packers | Washington Football Team | 24:10 | 3 - 10 - 10 |
| 24/10/21 19:00 | 24/10/21 19:00 | Tennessee Titans | Kansas City Chiefs | 27:3 | 4 - 10 - 4 |
| 24/10/21 19:00 | 24/10/21 19:00 | New England Patriots | New York Jets | 54:13 | 3 - 10 - 10 |
| 24/10/21 19:00 | 24/10/21 19:00 | New York Giants | Carolina Panthers | 25:3 | 7 - 10 - 3 |
| 24/10/21 22:05 | 24/10/21 22:05 | Las Vegas Raiders | Philadelphia Eagles | 33:22 | 3 - 10 - 8 |
| 24/10/21 22:05 | 24/10/21 22:05 | Los Angeles Rams | Detroit Lions | 28:19 | 3 - 10 - 10 |
| 24/10/21 22:25 | 24/10/21 22:25 | Tampa Bay Buccaneers | Chicago Bears | 38:3 | 3 - 10 - 10 |
| 24/10/21 22:25 | 24/10/21 22:25 | Arizona Cardinals | Houston Texans | 31:5 | 3 - 10 - 10 |
| 25/10/21 2:20 | 25/10/21 2:20 | San Francisco 49ers | Indianapolis Colts | 18:30 | 4 - 10 - 4 |
| 26/10/21 2:15 | 26/10/21 2:15 | Seattle Seahawks | New Orleans Saints | 10:13 | 6 - 10 - 3 |