Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 25/09/21 13:30 | 25/09/21 13:30 | Manchester United | Aston Villa | 0:1 | 5 - 7 puntos |
| 25/09/21 13:30 | 25/09/21 13:30 | FC Chelsea | Manchester City | 0:1 | 5 - 7 puntos |
| 25/09/21 16:00 | 25/09/21 16:00 | Leeds United | West Ham United | 1:2 | 5 - 7 puntos |
| 25/09/21 16:00 | 25/09/21 16:00 | Leicester City | FC Burnley | 2:2 | 5 - 7 puntos |
| 25/09/21 16:00 | 25/09/21 16:00 | FC Watford | Newcastle United | 1:1 | 5 - 7 puntos |
| 25/09/21 16:00 | 25/09/21 16:00 | FC Everton | Norwich City | 2:0 | 5 - 7 puntos |
| 25/09/21 18:30 | 25/09/21 18:30 | Brentford FC | Liverpool FC | 3:3 | 5 - 7 puntos |
| 26/09/21 15:00 | 26/09/21 15:00 | FC Southampton | Wolverhampton Wanderers | 0:1 | 5 - 7 puntos |
| 26/09/21 17:30 | 26/09/21 17:30 | Arsenal FC | Tottenham | 3:1 | 5 - 7 puntos |
| 27/09/21 21:00 | 27/09/21 21:00 | Crystal Palace | Brighton and Hove Albion | 1:1 | 5 - 7 puntos |