| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 4/12/21 22:00 | Deportes La Serena | Santiago Wanderers | 0:0 |
| 4/12/21 22:00 | Everton | Universidad Católica | 0:3 |
| 4/12/21 22:00 | Palestino | Ñublense | 1:4 |
| 4/12/21 22:00 | CD Antofagasta | Colo-Colo | 1:0 |
| 5/12/21 22:00 | Unión Española | Cobresal | 0:1 |
| 5/12/21 22:00 | Huachipato | Deportes Melipilla | 3:1 |
| 5/12/21 22:00 | Audax Italiano | Curico Unido | 1:1 |
| 5/12/21 22:00 | Universidad de Chile | Unión La Calera | 3:2 |