| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 8/05/21 18:00 | CD Godoy Cruz | CA Banfield | 0:1 |
| 8/05/21 20:30 | Gimnasia y Esgrima La Plata | CA Vélez Sarsfield | 0:5 |
| 8/05/21 20:30 | Atletico Tucuman | Defensa y Justicia | 5:0 |
| 8/05/21 23:00 | CA Patronato Parana | Boca Juniors | 1:0 |
| 9/05/21 15:00 | Arsenal de Sarandi | Central Córdoba | 1:1 |
| 9/05/21 17:10 | Argentinos Juniors | Estudiantes de La Plata | 2:0 |
| 9/05/21 19:30 | Racing Club | CA San Lorenzo | 2:0 |
| 9/05/21 19:30 | CA Platense | Rosario Central | 4:1 |
| 9/05/21 19:30 | River Plate | CA Aldosivi | 4:1 |
| 9/05/21 23:00 | CA Huracan | Independiente | 1:3 |
| 9/05/21 23:00 | CA Lanus | CA Talleres | 1:0 |
| 9/05/21 23:00 | Club Atlético Colón | Union Santa Fe | 1:1 |
| 10/05/21 2:00 | Newell's Old Boys | CA Sarmiento Junin | 1:1 |